Immunogenic measles antigens expressed in plants: role as an edible vaccine for adults

Claude P Muller; Estelle Marquet-Blouin; Fred Fack; Benjamin Damien; Andŕe Steinmetz; Fabienne B Bouche

doi:10.1016/s0264-410x(02)00606-0

Immunogenic measles antigens expressed in plants: role as an edible vaccine for adults

Vaccine. 2003 Jan 30;21(7-8):816-9. doi: 10.1016/s0264-410x(02)00606-0.

Authors

Claude P Muller¹, Estelle Marquet-Blouin, Fred Fack, Benjamin Damien, Andŕe Steinmetz, Fabienne B Bouche

Affiliation

¹ Department of Immunology and WHO Collaborative Center for Measles, Laboratoire National de Santé, PO Box 1102, 20A rue Auguste Lumière, L-1950, Luxembourg, Luxembourg. claude.muller@lns.etat.lu

PMID: 12531367
DOI: 10.1016/s0264-410x(02)00606-0

Abstract

Vaccine-induced immunity against measles is less robust than natural immunity. Waning of immunity in vaccines may eventually require a revaccination of adults. Measles antigens expressed in plants have been shown to be antigenic and immunogenic both after invasive and oral vaccination. Strategies for the vaccination of adults, the potential of an oral measles vaccine produced in edible plants and the design of suitable antigens are discussed.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Administration, Oral
Adult
Animals
Antigens, Viral / biosynthesis*
Antigens, Viral / genetics
Humans
Measles / prevention & control
Measles Vaccine / administration & dosage*
Measles Vaccine / immunology
Plants, Genetically Modified / genetics
Plants, Genetically Modified / metabolism*
Vaccines, Edible / administration & dosage
Vaccines, Edible / immunology

Substances

Antigens, Viral
Measles Vaccine
Vaccines, Edible