Novel orthogonal strategy toward solid-phase synthesis of 1,3,5-substituted triazines

Jacqueline T Bork; Jae Wook Lee; Sonya M Khersonsky; Ho-Sang Moon; Young-Tae Chang

doi:10.1021/ol027195v

Novel orthogonal strategy toward solid-phase synthesis of 1,3,5-substituted triazines

Org Lett. 2003 Jan 23;5(2):117-20. doi: 10.1021/ol027195v.

Authors

Jacqueline T Bork¹, Jae Wook Lee, Sonya M Khersonsky, Ho-Sang Moon, Young-Tae Chang

Affiliation

¹ Department of Chemistry, New York University, New York, New York 10003, USA.

PMID: 12529119
DOI: 10.1021/ol027195v

Abstract

[reaction: see text] To improve upon the previous orthogonal method for synthesis of a triazine library, an alternative strategy has been developed via oxidation-activation of the thioether to the sulfone. Through a comparison between these two methods, the sulfone strategy was demonstrated as an enhanced method in the generation of highly pure triazine library compounds.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Combinatorial Chemistry Techniques*
Resins, Synthetic
Triazines / chemical synthesis*
Tubulin Modulators

Substances

Resins, Synthetic
Triazines
Tubulin Modulators