Apatite-forming ability and mechanical properties of CaO-free poly(tetramethylene oxide) (PTMO)-TiO2 hybrids treated with hot water

Biomaterials. 2003 Apr;24(8):1357-63. doi: 10.1016/s0142-9612(02)00513-6.

Abstract

Poly(tetramethylene oxide) (PTMO)-TiO(2) hybrids were prepared by a sol-gel method from triethoxysilane-functionalized PTMO (Si-PTMO) and tetraisopropyltitanate with weight ratios of 30/70, 40/60 and 50/50 (hybrids PT30, PT40 and PT50, respectively), and subsequently subjected to a hot-water treatment at 95 degrees C for 2 d. All the obtained hybrids were amorphous before the hot-water treatment, and precipitated nanosized anatase after the hot-water treatment. The amount of precipitated anatase increased with decreasing PTMO content. Apatite was not formed on the surfaces of the hybrids in a simulated body fluid before the hot-water treatment, but was formed after the hot-water treatment, and its amount increased with decreasing PTMO content. Hybrid PT40 showed strength and Young's modulus analogous to those of human cancellous bones, and high ductility after the hot-water treatment. This kind of hybrid is expected to be useful as a new type of bone-repairing material.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Apatites / metabolism*
  • Biocompatible Materials*
  • Biomechanical Phenomena
  • Bone Substitutes
  • Ceramics
  • Chemical Precipitation
  • Hot Temperature
  • Humans
  • In Vitro Techniques
  • Materials Testing
  • Microscopy, Electron, Scanning
  • Oxides*
  • Titanium*
  • Water

Substances

  • Apatites
  • Biocompatible Materials
  • Bone Substitutes
  • Oxides
  • polytetramethyloxide
  • Water
  • titanium dioxide
  • Titanium