[Study on anticancer activity of Syngnathus in vitro]

Zhongguo Zhong Yao Za Zhi. 2001 Mar;26(3):198-200.
[Article in Chinese]

Abstract

Objective: To study the anticancer activity of Syngnathus in vitro.

Method: Observing the influence of different extracts from Syngnathus on growth of different cancer cell strains by MTT method.

Result: It has been found out that the fat-soluble nonsaponified extract from Temminck et Schlegel and the alcoholic extract from Syngnathus acus have cytotoxic activities. The nonsaponified extract from Temminck et Schlegel can inhibit the growth of cancer cell strains KB, Hela, PAA, K562, and Bcap37, and the alcoholic extract from Syngnathus acus can inhibit the growth of cancer cell strin KB, But Bloch shows no apparent anticancer activity.

Conclusion: Syngnathus has promising prospects as an anticancer Chinese medicine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacology*
  • Cell Division / drug effects
  • Fishes*
  • HeLa Cells / drug effects
  • Humans
  • K562 Cells / drug effects
  • Materia Medica / pharmacology*
  • Prohibitins
  • Tetrazolium Salts
  • Thiazoles
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents
  • Materia Medica
  • PHB2 protein, human
  • Prohibitins
  • Tetrazolium Salts
  • Thiazoles
  • thiazolyl blue