Abstract
Human immunodeficiency virus type 1 plasma viruses from 29 entry inhibitor-naive patients were characterized for their susceptibilities to T-20, AMD3100, and RANTES. A strikingly wide range of susceptibilities to T-20 was observed that was influenced by coreceptor usage but not by the susceptibilities of the viruses to inhibitors that target the chemokine receptors or by polymorphisms in the gp41 N helix.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Anti-HIV Agents / pharmacology*
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Cell Line
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HIV Envelope Protein gp41 / genetics
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HIV-1 / drug effects*
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HIV-1 / genetics
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HIV-1 / physiology
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Humans
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Membrane Fusion / drug effects*
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Molecular Sequence Data
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Polymorphism, Genetic
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Receptors, CCR5 / drug effects
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Receptors, CXCR4 / drug effects
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Sequence Homology, Amino Acid
Substances
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Anti-HIV Agents
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HIV Envelope Protein gp41
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Receptors, CCR5
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Receptors, CXCR4