Abstract
We report a case of a patient with two B-cell lymphoproliferative disorders: CD5(-)/CD23(+) B-cell chronic lymphocytic leukemia and CD5(+)/CD23(-) mantle cell lymphoma. These disorders were diagnosed simultaneously based on flow cytometry, immunohistochemistry, fluorescence in situ hybridization, and polymerase chain reaction-based molecular studies. The B-cell lymphocytic leukemia clone predominated in the blood and bone marrow, whereas the mantle cell clone predominated in lymph nodes.
Copyright 2002 Wiley-Liss, Inc.
MeSH terms
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Aged
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Aged, 80 and over
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CD5 Antigens / analysis
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Chromosomes, Human, Pair 11
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Chromosomes, Human, Pair 13
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Chromosomes, Human, Pair 14
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Flow Cytometry
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Humans
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Leukemia, Lymphocytic, Chronic, B-Cell / complications
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Leukemia, Lymphocytic, Chronic, B-Cell / genetics*
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Leukemia, Lymphocytic, Chronic, B-Cell / pathology*
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Lymph Nodes / pathology
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Lymphoma, Mantle-Cell / complications
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Lymphoma, Mantle-Cell / genetics*
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Lymphoma, Mantle-Cell / pathology*
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Male
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Receptors, IgE / analysis
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Translocation, Genetic*
Substances
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CD5 Antigens
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Receptors, IgE