Fluvoxamine suppresses the long-term potentiation in the hippocampal CA1 field of anesthetized rats: an effect mediated via 5-HT1A receptors

Brain Res. 2003 Jan 3;959(1):165-8. doi: 10.1016/s0006-8993(02)03756-3.

Abstract

A selective 5-HT reuptake inhibitor, fluvoxamine (10 and 30 mg/kg, i.p.) suppressed long-term potentiation (LTP) in the hippocampal CA1 field of anesthetized rats. Fluvoxamine (30 mg/kg, i.p.)-induced suppression of LTP was completely reversed by the 5-HT(1A) receptor antagonist NAN-190 (0.5 mg/kg, i.p), but not by the 5-HT(4) receptor antagonist GR 113808 (20 microg/rat, i.c.v.) and the 5-HT(7) receptor antagonist DR 4004 (10 microg/rat, i.c.v.). These data suggest that the inhibitory effect of fluvoxamine on LTP induction is mediated via 5-HT(1A) receptors.

MeSH terms

  • Animals
  • Evoked Potentials / drug effects
  • Evoked Potentials / physiology
  • Fluvoxamine / pharmacology*
  • Hippocampus / drug effects*
  • Hippocampus / physiology*
  • Long-Term Potentiation / drug effects*
  • Long-Term Potentiation / physiology
  • Male
  • Neuronal Plasticity / drug effects
  • Neuronal Plasticity / physiology
  • Piperazines / pharmacology
  • Rats
  • Rats, Wistar
  • Receptors, Serotonin / metabolism
  • Receptors, Serotonin, 5-HT1
  • Selective Serotonin Reuptake Inhibitors / pharmacology*
  • Serotonin Antagonists / pharmacology

Substances

  • Piperazines
  • Receptors, Serotonin
  • Receptors, Serotonin, 5-HT1
  • Serotonin Antagonists
  • Serotonin Uptake Inhibitors
  • 1-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine
  • Fluvoxamine