Abstract
The isopeptide bonds formed by ubiquitin or its relatives are cleaved by hydrolases with active site cysteines. Recent studies have revealed that similar metalloprotease motifs--JAMMs--in the Rpn11 subunit of the 26S proteasome lid and in the Csn5 subunit of the COP9 signalosome are involved in deubiquitination and deneddylation, respectively.
MeSH terms
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Metalloendopeptidases / metabolism*
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Peptide Hydrolases / metabolism*
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Proteasome Endopeptidase Complex*
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Protein Subunits
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Saccharomyces cerevisiae / enzymology
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Signal Transduction
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Ubiquitin / metabolism*
Substances
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Protein Subunits
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Ubiquitin
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Peptide Hydrolases
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Metalloendopeptidases
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Proteasome Endopeptidase Complex
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ATP dependent 26S protease