Objective: To explore the biological reaction of swine acellular dermal matrix as a filling material for body surface deformity.
Methods: Xenogenic acellular dermal matrix was implanted into the hypoderm of rabbits. The implants were measured and observed with pathological and transmission electron microscopic technique at regular times. The results were compared with implantation of autologous dermis and swine dermis.
Results: The implanted xenogenic acellular dermal matrix and autologous dermis had slight inflammatory reaction. At 2 weeks there were fibroblasts and capillaries in the implants. The absorptivity of the xenogenic acellular dermal matrix was lower than the swine dermis. The xenogenic acellular dermal matrix was used in 2 clinical cases and obtained good result.
Conclusion: The xenogenic acellular dermal matrix is an ideal material with good compatibility feature and low absorptivity.