The palladium(II) centre in the title compound, [PdCl(2)(C(21)H(18)N(2)OS)], is coordinated to the pyridyl N atom and to the thiazolidinone S atom of the 5-benzyl-3-phenyl-2-(2-pyridyl)thiazolidin-4-one ligand, resulting in a five-membered chelate ring. Two cis-chloro ligands complete the square-planar coordination environment of the metal. Although the geometry at the Pd centre is essentially planar, the N-Pd-S bite angle of 85.20 (8) degrees causes deviations in the cis angles from the ideal value of 90 degrees. Opposite enantiomers form one-dimensional chains in the cell via a short S.O intermolecular interaction.