Abstract
[reaction: see text] A concise, stereocontrolled synthesis of sphingofungin F was achieved. Key features involve diastereoselective oxazoline formation catalyzed by palladium(0), MgBr(2)-promoted gamma-alkoxy allylic stannane addition, and palladium(0)-catalyzed coupling of a vinyl iodide with an organozinc reagent.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acids / chemical synthesis*
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Amino Acids / chemistry*
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Antifungal Agents / chemical synthesis*
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Antifungal Agents / chemistry*
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Catalysis
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Fatty Acids, Unsaturated / chemical synthesis*
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Fatty Acids, Unsaturated / chemistry*
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Molecular Structure
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Palladium / chemistry
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Stereoisomerism
Substances
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Amino Acids
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Antifungal Agents
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Fatty Acids, Unsaturated
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sphingofungin F
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Palladium