The diffusion of a chemical disinfectant into wastewater particles may be viewed as a serial two-step process involving transport through a macroporous network of pathways to micropores that lead into dense cellular regions. Previous research reveals that ultraviolet (UV) light penetration into wastewater particles is limited primarily to macropores, resulting in a residual concentration of targeted organisms in post-disinfected effluents that reflects the number of organisms embedded in the dense cellular regions of particles. Conversely, chlorine was demonstrated as part of this research to penetrate into both the macroporous and microporous network of pathways, implying that the application of chlorine may be designed feasibly to achieve a desired level of inactivation of particle-associated organisms. In the short term, a disinfection model previously developed for UV irradiation may be used to assess the inactivation of particle-associated organisms with chlorine. However, in the long-term, a more rigorous and complete understanding of the transport of chemical disinfectants into particles can be explored utilizing existing mathematical expressions commonly used to model mass transport into porous media. The parameters of interest in this modeling approach include the reaction rate of chlorine with particulate material, the diffusion rate of chlorine within a particle, the mass-transfer rate coefficient across the particle's boundary, and the particle porosity.