Abstract
Phytochemical investigations on the non-alkaloidal extracts of Mitragyna stipulosa bark has led to the isolation of a series of triterpenoids mainly consisting of quinovic acid ([structure: see text]) and its glycoside derivatives [structure: see text] and [structure: see text]. The other constituents isolated include alpha-amyrin, 3beta-acetyl ursolic acid and a mixture of oleanolic and ursolic acid and beta-sitosterol glucopyranoside. Their structures were identified by spectral and chemical studies and compounds [structure: see text] and [structure: see text] were, respectively, identified as quinovic acid 3-O-[beta-D-glucopyranoside] (quinovin glycoside C) and quinovic acid 3-O-[beta-D-quinovopyranoside]-27-O-[beta-D-glucopyranosyl] ester. Compounds [structure: see text] and [structure: see text] showed significant inhibitory activity against snake venom phosphodiesterase I.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cameroon
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Glucosides / chemistry
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Glucosides / isolation & purification
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Glucosides / pharmacology
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Mitragyna / chemistry*
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Oleanolic Acid / chemistry
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Oleanolic Acid / isolation & purification
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Phosphodiesterase Inhibitors / chemistry
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Phosphodiesterase Inhibitors / isolation & purification*
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Phosphodiesterase Inhibitors / pharmacology
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Plant Bark / chemistry
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Plant Extracts / chemistry
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Plants, Medicinal / chemistry*
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Snake Venoms / antagonists & inhibitors*
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Stereoisomerism
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Triterpenes / chemistry
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Triterpenes / isolation & purification*
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Triterpenes / pharmacology
Substances
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Glucosides
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Phosphodiesterase Inhibitors
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Plant Extracts
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Snake Venoms
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Triterpenes
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quinovic acid 3-O-quinovopyranoside-27-O-glucopyranosyl ester
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quinovin glycoside C
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Oleanolic Acid
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quinovic acid
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beta-amyrin