Phytochemical investigation of leaves and twigs of Gnidia socotrana (Balf. f.) Gilg (Thymelaeaceae), a plant occurring endemically on Socotra Island (Yemen), afforded six novel natural products: two compounds consisting of a flavone and a coumarin moiety connected by a C-C linkage, 7,7'-dihydroxy-3,8'-biscoumarin and three substances with the rare spiro-bis-gamma-lactone structure. The structures were elucidated on the basis of their spectroscopic data.