Cytotoxic amides from Piper sintenense

Planta Med. 2002 Nov;68(11):980-5. doi: 10.1055/s-2002-35660.

Abstract

A new alkaloid, pipersintenamide ( 1), together with fourteen known compounds, have been isolated from the whole plant of Piper sintenense. The structures of these compounds were elucidated by spectroscopic analysis. Pipersintenamide, sintenpyridone, sarmentine, and 1-(3,4-methylenedioxyphenyl)-1 E-dodecene at 20 microg/ml exhibited effective cytotoxicities (cell survival < 15 %) against CCRF-CEM, HL-60, PC-3, and HA22T cell lines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkenes / pharmacology*
  • Alkenes / therapeutic use
  • Animals
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Antineoplastic Agents, Phytogenic / therapeutic use
  • Cell Division / drug effects*
  • Cell Survival / drug effects*
  • Humans
  • Inhibitory Concentration 50
  • Magnetic Resonance Spectroscopy
  • Muscle, Smooth, Vascular / cytology
  • Muscle, Smooth, Vascular / drug effects
  • Phytotherapy*
  • Piper*
  • Piperidines / pharmacology*
  • Piperidines / therapeutic use
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use
  • Rats
  • Tumor Cells, Cultured / drug effects

Substances

  • Alkenes
  • Antineoplastic Agents, Phytogenic
  • Piperidines
  • Plant Extracts
  • pipersintenamide