[The immunometaboic effects of benfotiamine and riboxine on hemolytic anemia]

B S Uteshev; G A Lazareva; L G Prokopenko

[The immunometaboic effects of benfotiamine and riboxine on hemolytic anemia]

Eksp Klin Farmakol. 2002 Jul-Aug;65(4):37-41.

[Article in Russian]

Authors

B S Uteshev¹, G A Lazareva, L G Prokopenko

Affiliation

¹ Pharmacology Department, State Medical University, ul. Ostrovityanova 1, Moscow, 117437 Russia.

PMID: 12449073

Abstract

Single (80 mg/kg) or multiply repeated (30 mg/kg) intramuscular injections of phenylhydrazine decrease the functional activity of mononuclear blood cells and the reduces immunological reactivity of the organism. Benfotiamine and riboxin decrease the extent of changes in the immunological response to a single administration of phenylhydrazine but do not significantly influence the immunological functions impaired by repeated injections of the hemolytic toxin.

Publication types

English Abstract

MeSH terms

Adjuvants, Immunologic / therapeutic use*
Anemia, Hemolytic / blood
Anemia, Hemolytic / drug therapy
Anemia, Hemolytic / immunology*
Animals
Antibody Formation / drug effects
Disease Models, Animal
Hypersensitivity, Delayed / immunology
Inosine Diphosphate / therapeutic use*
Leukocytes, Mononuclear / immunology*
Phagocytosis / drug effects
Phenylhydrazines
Rats
Rats, Wistar
Thiamine / analogs & derivatives*
Thiamine / therapeutic use*

Substances

Adjuvants, Immunologic
Phenylhydrazines
phenylhydrazine
Inosine Diphosphate
Thiamine
benphothiamine