Abstract
Ten intraperitoneal injections of tripeptide Gly-His-Lys in doses of 1.5, 5, 50, 150, and 450 mg/kg stimulated mitotic activity of hepatocytes and dose-dependently suppressed immune reactivity (number of antibody-producing cells and delayed-type hypersensitivity reaction).
MeSH terms
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Amino Acid Sequence
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Animals
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Antibody Formation
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Dose-Response Relationship, Immunologic
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Hepatocytes / drug effects*
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Hepatocytes / metabolism
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Hypersensitivity, Delayed / prevention & control
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Immunization, Passive
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Immunosuppressive Agents / chemistry
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Immunosuppressive Agents / pharmacology*
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Mice
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Mice, Inbred CBA
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Mitotic Index
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Oligopeptides / chemistry
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Oligopeptides / pharmacology*
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Rats
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Rats, Wistar
Substances
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Immunosuppressive Agents
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Oligopeptides
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glycyl-histidyl-lysine