Tripeptide Gly-His-Lys is a hepatotropic immunosuppressor

Bull Exp Biol Med. 2002 Jun;133(6):586-7. doi: 10.1023/a:1020242127443.

Abstract

Ten intraperitoneal injections of tripeptide Gly-His-Lys in doses of 1.5, 5, 50, 150, and 450 mg/kg stimulated mitotic activity of hepatocytes and dose-dependently suppressed immune reactivity (number of antibody-producing cells and delayed-type hypersensitivity reaction).

Publication types

  • Comparative Study

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antibody Formation
  • Dose-Response Relationship, Immunologic
  • Hepatocytes / drug effects*
  • Hepatocytes / metabolism
  • Hypersensitivity, Delayed / prevention & control
  • Immunization, Passive
  • Immunosuppressive Agents / chemistry
  • Immunosuppressive Agents / pharmacology*
  • Mice
  • Mice, Inbred CBA
  • Mitotic Index
  • Oligopeptides / chemistry
  • Oligopeptides / pharmacology*
  • Rats
  • Rats, Wistar

Substances

  • Immunosuppressive Agents
  • Oligopeptides
  • glycyl-histidyl-lysine