Abstract
Upon antigen recognition, T cells undergo substantial membrane and cytoskeletal rearrangements that lead to the formation of the immunological synapse and are necessary for subsequent T-cell activation. However, little is known about how membrane and cytoskeletal molecules interact during these processes. Here we discuss the involvement of the membrane-microfilament linker ezrin. We propose that ezrin is a component of the cytoskeleton-mediated architecture of the immunological synapse that plays a role in T-cell receptor clustering, protein kinase C theta translocation and intracellular signaling.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
4-Butyrolactone / analogs & derivatives*
-
4-Butyrolactone / immunology
-
Actins / immunology
-
Animals
-
Antigen-Presenting Cells / immunology
-
CD3 Complex / metabolism
-
Cell Polarity
-
Cytoskeletal Proteins
-
Cytoskeleton / immunology*
-
Humans
-
Image Processing, Computer-Assisted
-
Intercellular Junctions / immunology*
-
Lymphocyte Activation
-
Mice
-
Models, Immunological
-
Phosphoproteins / chemistry
-
Phosphoproteins / immunology
-
Receptors, Antigen, T-Cell / metabolism
-
T-Lymphocytes / immunology*
Substances
-
Actins
-
CD3 Complex
-
Cytoskeletal Proteins
-
Phosphoproteins
-
Receptors, Antigen, T-Cell
-
coronin
-
ezrin
-
4-Butyrolactone