New saponins from the starfish Certonardoa semiregularis

J Nat Prod. 2002 Nov;65(11):1649-56. doi: 10.1021/np020234r.

Abstract

Ten new saponins designated as certonardosides A-J (1-5, 7-11) and the known halityloside D (6) were isolated from the brine shrimp active fraction of the MeOH extract of the starfish Certonardoa semiregularis. The structures were determined on the basis of spectral analysis and chemical manipulation. The compounds were evaluated for antiviral activity against HIV, HSV, CoxB, EMCV, and VSV and displayed insignificant activity within the range of noncytotoxic concentrations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology
  • Antiviral Agents / chemistry
  • Antiviral Agents / isolation & purification*
  • Antiviral Agents / pharmacology
  • Artemia
  • HeLa Cells / drug effects
  • Humans
  • Korea
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Saponins / chemistry
  • Saponins / isolation & purification*
  • Saponins / pharmacology
  • Starfish / chemistry*
  • Stereoisomerism
  • Steroids / chemistry
  • Steroids / isolation & purification*
  • Steroids / pharmacology

Substances

  • Antineoplastic Agents
  • Antiviral Agents
  • Saponins
  • Steroids
  • halityloside D