A unique amino acid deletion in the chimpanzee Cyclin T1 does not affect Tat trans-activation of HIV

AIDS. 2002 Nov 22;16(17):2335-7. doi: 10.1097/00002030-200211220-00015.

Abstract

We have cloned and sequenced the chimpanzee (Pan troglodytes) cyclin T1 cDNA and performed functional HIV-1 Tat trans-activation studies. A unique codon deletion leading to a deleted asparagine residue in the N-terminal region of the first cyclin domain was discovered. This mutation does not significantly change the trans-activation of HIV-1, suggesting that Tat-Cyclin T1 mediated transcription is not a major barrier to HIV replication in the chimpanzee.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence
  • Cyclins / genetics*
  • Female
  • Gene Deletion*
  • Gene Products, tat
  • HIV-1 / genetics*
  • Male
  • Molecular Sequence Data
  • Pan troglodytes / virology*
  • Transcriptional Activation*
  • tat Gene Products, Human Immunodeficiency Virus

Substances

  • Cyclins
  • Gene Products, tat
  • tat Gene Products, Human Immunodeficiency Virus

Associated data

  • GENBANK/AF520776
  • RefSeq/NM_009833