Antimalarial chemotherapeutic peroxides: artemisinin, yingzhaosu A and related compounds

Kristina Borstnik; Ik-hyeon Paik; Theresa A Shapiro; Gary H Posner

doi:10.1016/s0020-7519(02)00195-9

Antimalarial chemotherapeutic peroxides: artemisinin, yingzhaosu A and related compounds

Int J Parasitol. 2002 Dec 4;32(13):1661-7. doi: 10.1016/s0020-7519(02)00195-9.

Authors

Kristina Borstnik¹, Ik-hyeon Paik, Theresa A Shapiro, Gary H Posner

Affiliation

¹ Department of Chemistry, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218-2685, USA.

PMID: 12435451
DOI: 10.1016/s0020-7519(02)00195-9

Abstract

Mechanism-based rational design and gram-scale chemical synthesis have produced some new trioxane and endoperoxide antimalarial drug candidates that are efficacious and safe. This review summarises recent achievements in this area of peroxide drug development for malaria chemotherapy.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Animals
Antimalarials / pharmacology*
Artemisinins / pharmacology*
Bridged Bicyclo Compounds, Heterocyclic / pharmacology*
Drug Design
Peroxides*
Plasmodium / drug effects*
Sesquiterpenes / pharmacology*

Substances

Antimalarials
Artemisinins
Bridged Bicyclo Compounds, Heterocyclic
Peroxides
Sesquiterpenes
yingzhaosu A
artemisinin

Abstract

Publication types

MeSH terms

Substances

Grants and funding