Objective: The aim of the study was to test the hypothesis that increased maternal age is associated with a higher risk of having a child with oral clefts.
Study design: A meta-analysis of 8 population-based studies with information regarding live birth and oral clefts was performed.
Results: No association between increased maternal age and isolated oral clefts was found.
Conclusion: Oral clefts occurrence is not correlated with increasing maternal age, and inclusion of data mixing isolated and syndromic cases can confound the analysis and must be avoided.