Studies on effect of simulated microgravity on cardiovascular function and counter effect of lower body negative pressure (LBNP) in recent years were summarized. The mechanism of simulated microgravity induced orthostatic intolerance may involve the reduction of cardiovascular function and cerebral blood flow, and endocrine changes. The significance of mathematical model in the study of mechanism of microgravity induced orthostatic intolerance was also discussed. The counter effect of LBNP was emphasized.