4-[6-(Dansylamino)hexylamino]-7-methyl-2-phenyl-1,8-naphthyridine as a new potential fluorescent probe for studying A1-adenosine receptor

Farmaco. 2002 Oct;57(10):783-6. doi: 10.1016/s0014-827x(02)01275-2.

Abstract

A new fluorescent ligand for adenosine receptors, obtained by the insertion of a dansylamino-moiety with a linear hexyl spacer in the N4 position of a 1,8-naphthyridine adenosine receptor ligand, proved to possess a high affinity and selectivity for the A1 receptor subtype.

MeSH terms

  • Animals
  • Binding, Competitive
  • Cattle
  • Cell Membrane / metabolism
  • Cerebral Cortex / metabolism
  • Dansyl Compounds / chemical synthesis
  • Dansyl Compounds / chemistry*
  • Fluorescent Dyes / chemical synthesis
  • Fluorescent Dyes / chemistry*
  • Fluorescent Dyes / metabolism
  • Humans
  • Kinetics
  • Naphthyridines / chemical synthesis
  • Naphthyridines / chemistry*
  • Naphthyridines / metabolism
  • Radioligand Assay
  • Receptors, Purinergic P1 / chemistry
  • Receptors, Purinergic P1 / metabolism*

Substances

  • 4-(6-(dansylamino)hexylamino)-7-methyl-2-phenyl-1,8-naphthyridine
  • Dansyl Compounds
  • Fluorescent Dyes
  • Naphthyridines
  • Receptors, Purinergic P1