Antidisialosyl antibodies in chronic idiopathic ataxic neuropathy

J Neurol. 2002 Nov;249(11):1525-8. doi: 10.1007/s00415-002-0882-2.

Abstract

Antidisialosyl antibodies were found in two out of 13 patients with chronic idiopathic ataxic neuropathy (CIAN) and not in 32 patients with different sensory neuropathies of known cause. This finding confirms the association of antidisialosyl antibodies and CIAN regardless of the absence of the M band. These antibodies may have pathogenic relevance; however, larger series are needed to establish their clinical significance.

MeSH terms

  • Aged
  • Ataxia / immunology*
  • Ataxia / physiopathology
  • Autoantibodies / immunology*
  • Autoantibodies / metabolism
  • Chronic Disease
  • Cisplatin / toxicity
  • Female
  • Ganglia, Spinal / immunology*
  • Ganglia, Spinal / pathology
  • Ganglia, Spinal / physiopathology
  • Gangliosides / immunology*
  • Gangliosides / metabolism
  • Humans
  • Immunoglobulin G / blood
  • Immunoglobulin G / immunology
  • Immunoglobulin M / blood
  • Immunoglobulin M / immunology
  • Male
  • Middle Aged
  • Neurons, Afferent / immunology*
  • Neurons, Afferent / metabolism
  • Neurons, Afferent / pathology
  • Paraneoplastic Polyneuropathy / immunology
  • Peripheral Nervous System Diseases / immunology*
  • Peripheral Nervous System Diseases / physiopathology
  • Sjogren's Syndrome / immunology

Substances

  • Autoantibodies
  • Gangliosides
  • Immunoglobulin G
  • Immunoglobulin M
  • disialosyl galactosyl globoside
  • Cisplatin