Effect of Sinpo-Tang on the mast cell-mediated anaphylactic reactions

Pharmacol Res. 2002 Nov;46(5):453-8. doi: 10.1016/s1043661802002037.

Abstract

The herbal formulation Sinpo-Tang (SPT) has long been used for various allergic diseases. We investigated the effect of SPT on the mast cell-mediated anaphylactic reactions in vivo and in vitro murine models. SPT dose dependently inhibited compound 48/80-induced ear swelling response and histamine release. SPT (0.001-0.1g/kg) significantly inhibited passive cutaneous anaphylaxis (PCA). The mast cell number was markedly decreased at the SPT-treated PCA site. In addition, SPT decreased intracellular calcium levels of activated mast cells. These results suggest that SPT inhibit the anaphylactic degranulation of mast cells through decrease of the intracellular calcium level.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anaphylaxis / immunology
  • Anaphylaxis / prevention & control*
  • Animals
  • Calcium / metabolism
  • Disease Models, Animal
  • Edema / chemically induced
  • Edema / immunology
  • Histamine Release / drug effects
  • Korea
  • Mast Cells / drug effects*
  • Mast Cells / immunology
  • Mast Cells / metabolism
  • Medicine, East Asian Traditional*
  • Mice
  • Mice, Inbred ICR
  • Passive Cutaneous Anaphylaxis / drug effects
  • Passive Cutaneous Anaphylaxis / immunology
  • Phytotherapy*
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use
  • Rats
  • Rats, Wistar
  • p-Methoxy-N-methylphenethylamine / pharmacology

Substances

  • Plant Extracts
  • p-Methoxy-N-methylphenethylamine
  • Calcium