DICER-LIKE1: blind men and elephants in Arabidopsis development

Trends Plant Sci. 2002 Nov;7(11):487-91. doi: 10.1016/s1360-1385(02)02355-5.

Abstract

Genetic studies of embryo, ovule and flower development in Arabidopsis thaliana have led to the independent isolation of different mutant alleles of a single gene (SIN1/SUS1/CAF, now renamed DCL1) that encodes a complex RNA-processing enzyme. DCL1 shows similarity to the Dicer group of genes, which are required for RNA silencing in Drosophila and Caenorhabditis. These recent findings identify a novel but conserved mechanism of post-transcriptional gene regulation that is important for development in eukaryotes.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Alleles
  • Arabidopsis / genetics*
  • Arabidopsis / growth & development
  • Arabidopsis Proteins / genetics*
  • Arabidopsis Proteins / metabolism
  • Cell Cycle Proteins / genetics*
  • Cell Cycle Proteins / metabolism
  • Endoribonucleases / genetics*
  • Endoribonucleases / metabolism
  • Flowers / genetics
  • Flowers / growth & development
  • Genes, Plant / genetics
  • Mutation
  • RNA Interference
  • RNA, Plant / genetics
  • RNA, Plant / metabolism
  • Ribonuclease III
  • Seeds / genetics
  • Seeds / growth & development

Substances

  • Arabidopsis Proteins
  • Cell Cycle Proteins
  • RNA, Plant
  • Endoribonucleases
  • DCL1 protein, Arabidopsis
  • Ribonuclease III