Objective: To study the expression of cytokeratin in epithelial cells of nasal polyp and its significance.
Method: The monoclonal antibody of AE1, AE3, CK7, CK14, CK19, CK20 were used to determined the corresponding cytokeratin expression in epithelial cells of nasal polyp with immunohistochemical staining.
Result: 1. AE1, CK7, CK19 staining were positive in various pathological epithelium of nasal polyp. AE1, CK19 showed positive in total layer of epithelium. CK7 was positive in goblet cells and basal cells of the pseudostratified epithelium. 2. AE3, CK20 staining were positive in part of simple epithelium and stratified epithelium. 3. AE1, AE3, CK7, CK19 staining showed focal positive in transitional epithelium.
Conclusion: CK7, CK19 are the one of the essential assembly type of cytokeratin in epithelium of nasal polyp. During the process of inflammatory reaction, the expression of partial cytokeratin subtype would lose while a new cytokeratin pattern would appear.