Controllability of depth dose distribution for neutron capture therapy at the Heavy Water Neutron Irradiation Facility of Kyoto University Research Reactor

Med Phys. 2002 Oct;29(10):2338-50. doi: 10.1118/1.1509445.

Abstract

The updating construction of the Heavy Water Neutron Irradiation Facility of the Kyoto University Research Reactor has been performed from November 1995 to March 1996 mainly for the improvement in neutron capture therapy. On the performance, the neutron irradiation modes with the variable energy spectra from almost pure thermal to epi-thermal neutrons became available by the control of the heavy-water thickness in the spectrum shifter and by the open-and-close of the cadmium and boral thermal neutron filters. The depth distributions of thermal, epi-thermal and fast neutron fluxes were measured by activation method using gold and indium, and the depth distributions of gamma-ray absorbed dose rate were measured using thermo-luminescent dosimeter of beryllium oxide for the several irradiation modes. From these measured data, the controllability of the depth dose distribution using the spectrum shifter and the thermal neutron filters was confirmed.

MeSH terms

  • Antineoplastic Agents / therapeutic use*
  • Cadmium
  • Deuterium Oxide*
  • Hot Temperature*
  • Humans
  • Japan
  • Neutron Capture Therapy / instrumentation*
  • Neutron Capture Therapy / methods*
  • Neutrons / therapeutic use*
  • Phantoms, Imaging
  • Radiometry / methods*
  • Reproducibility of Results
  • Temperature
  • Water

Substances

  • Antineoplastic Agents
  • Cadmium
  • Water
  • Deuterium Oxide