[The role of HLA-B27 molecules in the pathogenesis of ankylosing spondylitis]

Reumatismo. 2002 Jul-Sep;54(3):266-71. doi: 10.4081/reumatismo.2002.266.
[Article in Italian]

Abstract

Ankylosing Spondylitis (AS) is characterised by the strongest association with an HLA antigen ever described for any disease. It represents therefore the ideal model for the understanding of the link between immune-mediated diseases and the HLA system. The role of HLA-B27 in the pathogenesis of AS will be discussed focusing on the recently described higher expression of these molecules in patients with AS compared with healthy controls.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Amino Acid Substitution
  • Animals
  • Animals, Genetically Modified
  • Antigen Presentation
  • Antigens, Bacterial / immunology
  • Autoantigens / genetics
  • Autoantigens / immunology
  • Autoimmune Diseases / etiology*
  • Autoimmune Diseases / immunology
  • CD8-Positive T-Lymphocytes / immunology
  • Clonal Deletion
  • Cytokines / biosynthesis
  • Ethnicity / genetics
  • Gene Expression
  • Genetic Heterogeneity
  • Genetic Predisposition to Disease
  • HLA-B27 Antigen / classification
  • HLA-B27 Antigen / genetics
  • HLA-B27 Antigen / immunology
  • HLA-B27 Antigen / physiology*
  • Humans
  • Klebsiella pneumoniae / immunology
  • Models, Biological
  • Molecular Mimicry
  • NF-kappa B / metabolism
  • Protein Folding
  • Rats
  • Shigella flexneri / immunology
  • Spondylitis, Ankylosing / etiology*
  • Spondylitis, Ankylosing / immunology

Substances

  • Antigens, Bacterial
  • Autoantigens
  • Cytokines
  • HLA-B27 Antigen
  • NF-kappa B