Pseudohyphal growth in a dimorphic yeast, Candida maltosa, after disruption of the C-GCN4 gene, a homolog of Saccharomyces cerevisiae GCN4

Hiroaki Takaku; Hiroyuki Horiuchi; Masamichi Takagi; Akinori Ohta

doi:10.1271/bbb.66.1936

Pseudohyphal growth in a dimorphic yeast, Candida maltosa, after disruption of the C-GCN4 gene, a homolog of Saccharomyces cerevisiae GCN4

Biosci Biotechnol Biochem. 2002 Sep;66(9):1936-9. doi: 10.1271/bbb.66.1936.

Authors

Hiroaki Takaku¹, Hiroyuki Horiuchi, Masamichi Takagi, Akinori Ohta

Affiliation

¹ Department of Biotechnology, University of Tokyo, Japan.

PMID: 12400694
DOI: 10.1271/bbb.66.1936

Abstract

The transcriptional activator protein Gcn4p increases the transcription of many genes that code for amino acid synthesis genes during amino acid starvation in Saccharomyces cerevisiae. Here we showed that after the disruption of C-GCN4, a homolog in Candida maltosa of GCN4 in S. cerevisiae, formed pseudohyphae in minimal medium. This is the first report that a GCN4 homolog is involved in the control of morphological transition.

MeSH terms

Candida / cytology
Candida / genetics*
Candida / growth & development*
DNA-Binding Proteins / genetics*
Gene Expression Regulation, Fungal
Genes, Fungal / genetics*
Mutation / genetics*
Protein Kinases / genetics*
RNA, Fungal / genetics
RNA, Fungal / metabolism
Saccharomyces cerevisiae Proteins / genetics*
Time Factors
Transcription, Genetic

Substances

DNA-Binding Proteins
RNA, Fungal
Saccharomyces cerevisiae Proteins
Protein Kinases