Component of Zingiber officinale that improves the enhancement of small intestinal transport

Kazunori Hashimoto; Kazuko Satoh; Pin Murata; Bunsho Makino; Iwao Sakakibara; Yoshio Kase; Atsushi Ishige; Masami Higuchi; Hiroshi Sasaki

doi:10.1055/s-2002-34928

Component of Zingiber officinale that improves the enhancement of small intestinal transport

Planta Med. 2002 Oct;68(10):936-9. doi: 10.1055/s-2002-34928.

Authors

Kazunori Hashimoto¹, Kazuko Satoh, Pin Murata, Bunsho Makino, Iwao Sakakibara, Yoshio Kase, Atsushi Ishige, Masami Higuchi, Hiroshi Sasaki

Affiliation

¹ Kampo & Pharmacognosy Laboratory, Tsumura & Co., Ami-machi, Ibaraki 300-1192, Japan. hashimoto_kazunori@mail.tsumura.co.jp

PMID: 12391562
DOI: 10.1055/s-2002-34928

Abstract

6-Shogaol, a constituent of Zingiber officinale, improved carbachol-induced accelerated small intestinal transit in vivo, as well as improving longitudinal muscle contraction induced by low-frequency electrical stimulation of the isolated guinea pig small intestine in vitro. In addition, 6-shogaol ameliorated BaCl(2) -induced hyperperistalsis of the small intestine in vivo.

MeSH terms

Animals
Barium Compounds
Catechols / administration & dosage
Catechols / pharmacology*
Chlorides
Electric Stimulation
Gastrointestinal Motility / drug effects*
Guinea Pigs
Humans
Intestine, Small / drug effects*
Intestine, Small / physiology
Muscle Contraction / drug effects*
Phytotherapy*
Plant Roots
Zingiber officinale*

Substances

Barium Compounds
Catechols
Chlorides
barium chloride
shogaol