Breakpoint medians and breakpoint phylogenies: a fixed-parameter approach

Bioinformatics. 2002:18 Suppl 2:S128-39. doi: 10.1093/bioinformatics/18.suppl_2.s128.

Abstract

With breakpoint distance, the genome rearrangement field delivered one of the currently most popular measures in phylogenetic studies for related species. Here, BREAKPOINT MEDIAN, which is NP-complete already for three given species (whose genomes are represented as signed orderings), is the core basic problem. For the important special case of three species, approximation (ratio 7/6) and exact heuristic algorithms were developed. Here, we provide an exact, fixed-parameter algorithm with provable performance bounds. For instance, a breakpoint median for three signed orderings over nelements that causes at most d breakpoints can be computed in time O((2.15)(d).n). We show the algorithm's practical usefulness through experimental studies. In particular, we demonstrate that a simple implementation of our algorithm combined with a new tree construction heuristic allows for a new approach to breakpoint phylogeny, yielding evolutionary trees that are competitive in comparison with known results developed in a recent series of papers that use clever algorithm engineering methods.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms*
  • Biological Evolution
  • Chromosome Mapping / methods*
  • Computer Simulation
  • Gene Rearrangement*
  • Models, Genetic*
  • Phylogeny*
  • Sequence Alignment / methods*
  • Sequence Analysis, DNA / methods*
  • Sequence Homology, Nucleic Acid