Parenteral administration of medium- but not long-chain lipid emulsions may increase the risk for infections by Candida albicans

Geert J Wanten; Mihai G Netea; Ton H Naber; Jo H Curfs; Liesbeth E Jacobs; Trees J Verver-Jansen; Bart-Jan Kullberg

doi:10.1128/IAI.70.11.6471-6474.2002

Parenteral administration of medium- but not long-chain lipid emulsions may increase the risk for infections by Candida albicans

Infect Immun. 2002 Nov;70(11):6471-4. doi: 10.1128/IAI.70.11.6471-6474.2002.

Authors

Geert J Wanten¹, Mihai G Netea, Ton H Naber, Jo H Curfs, Liesbeth E Jacobs, Trees J Verver-Jansen, Bart-Jan Kullberg

Affiliation

¹ Department of Gastroenterology, University Medical Center Nijmegen, Nijmegen, The Netherlands. G.Wanten@gastro.azn.nl

Abstract

Intravenous administration to volunteers of an emulsion of medium-chain lipids, but not of an emulsion of pure long-chain lipids or a placebo, increased the growth of Candida albicans in serum and modulated Candida-induced cytokine production by mononuclear cells in a way suggesting that medium-chain, but not long-chain, triglycerides increase the risk for infections by Candida.

Publication types

Clinical Trial

MeSH terms

Candida albicans / growth & development
Candidiasis / etiology*
Fat Emulsions, Intravenous / adverse effects*
Humans
Infusions, Intravenous
Interferon-gamma / biosynthesis
Neutrophils / immunology
Triglycerides / administration & dosage
Triglycerides / adverse effects*

Substances

Fat Emulsions, Intravenous
Triglycerides
Interferon-gamma