[Synthesis and pharmacological study of three 1-alkyl-3-(ethoxycarbonylmethylene)-2-oxo quinoxalines]

S Ferfra; A Zellou; E M Essassi; Y Cherrah; M Hassar

[Synthesis and pharmacological study of three 1-alkyl-3-(ethoxycarbonylmethylene)-2-oxo quinoxalines]

Ann Pharm Fr. 2002 Sep;60(5):341-4.

[Article in French]

Authors

S Ferfra¹, A Zellou, E M Essassi, Y Cherrah, M Hassar

Affiliation

¹ Laboratoire de Chimie Organique Hétérocyclique, Faculté des Sciences, BP 1014, Avenue Ibn Battouta, Rabat, Maroc, France.

PMID: 12378144

Abstract

The acute toxicity study and the psychotropic activity of three alkylated derivatives of 3-(ethoxycarbonylmethylene) -2-oxo quinoxaline did not demonstrate any toxicity of these products at therapeutic dosages. In the animal, these compounds have sedative, myorelaxant and anxiolytic properities.

Publication types

English Abstract

MeSH terms

Animals
Anti-Anxiety Agents / chemical synthesis
Anti-Anxiety Agents / pharmacology
Clorazepate Dipotassium / pharmacology
Drug Interactions
Hypnotics and Sedatives / chemical synthesis
Hypnotics and Sedatives / pharmacology
Male
Mice
Muscle Relaxants, Central / chemical synthesis
Muscle Relaxants, Central / pharmacology
Psychotropic Drugs / chemical synthesis*
Psychotropic Drugs / pharmacology
Psychotropic Drugs / toxicity
Quinoxalines / chemical synthesis*
Quinoxalines / pharmacology
Quinoxalines / toxicity
Rats
Rats, Wistar

Substances

Anti-Anxiety Agents
Hypnotics and Sedatives
Muscle Relaxants, Central
Psychotropic Drugs
Quinoxalines
Clorazepate Dipotassium