Abstract
The alkaloids, dechloroacutumidine and 1-epidechloroacutumine, together with three known alkaloids, acutumidine, acutumine, and dechloroacutumine, were isolated from the rhizomes of Menispermum dauricum and their structures established by spectral and chemical methods. The cytotoxicity of each compound against the growth of human cell lines was studied, and acutumine selectively inhibited T-cell growth.
MeSH terms
-
Alkaloids / chemistry*
-
Alkaloids / isolation & purification*
-
Alkaloids / pharmacology
-
B-Lymphocytes / drug effects
-
Cell Division / drug effects
-
Cell Line
-
Humans
-
Menispermum / chemistry*
-
Molecular Structure
-
Organ Specificity
-
Rhizome / chemistry
-
Spiro Compounds / isolation & purification
-
Spiro Compounds / pharmacology
-
T-Lymphocytes / cytology
-
T-Lymphocytes / drug effects
Substances
-
1-epidechloroacutumine
-
Alkaloids
-
Spiro Compounds
-
acutumine
-
dechloroacutumidine