Direct synthesis of guanidines using di(imidazole-1-yl)methanimine

Yong-Qian Wu; Sean K Hamilton; Douglas E Wilkinson; Gregory S Hamilton

doi:10.1021/jo0202381

Direct synthesis of guanidines using di(imidazole-1-yl)methanimine

J Org Chem. 2002 Oct 18;67(21):7553-6. doi: 10.1021/jo0202381.

Authors

Yong-Qian Wu¹, Sean K Hamilton, Douglas E Wilkinson, Gregory S Hamilton

Affiliation

¹ Department of Research, Guilford Pharmaceuticals, Inc., Baltimore, Maryland 21224, USA. wuy@guilfordpharm.com

PMID: 12375997
DOI: 10.1021/jo0202381

Abstract

A direct synthetic approach to guanidine compounds is reported here using di(imidazole-1-yl)methanimine and di(imidazole-1-yl)cyanomethanimine as guanylating reagents.

MeSH terms

Guanidines / chemical synthesis*
Guanidines / chemistry
Imidazoles
Indicators and Reagents
Magnetic Resonance Spectroscopy
Methylamines
Models, Molecular
Molecular Structure
Structure-Activity Relationship

Substances

Guanidines
Imidazoles
Indicators and Reagents
Methylamines