Novel nucleotide phosphonate analogues with potent antitumor activity

Bioorg Med Chem Lett. 2002 Nov 4;12(21):3063-6. doi: 10.1016/s0960-894x(02)00679-0.

Abstract

We have identified several nucleotide phosphonates demonstrating in vitro antiproliferative activity in several human cancer cell lines with IC(50) values in the microM range. The synthesis as well as structure-activity relationship are described.

MeSH terms

  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / pharmacology*
  • Drug Screening Assays, Antitumor
  • Furans / chemical synthesis*
  • Furans / pharmacology*
  • Humans
  • Nucleotides / chemical synthesis*
  • Nucleotides / pharmacology*
  • Organophosphonates / chemical synthesis*
  • Organophosphonates / pharmacology*
  • Structure-Activity Relationship
  • Thymidine / metabolism
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents
  • Furans
  • Nucleotides
  • Organophosphonates
  • tetrahydrofuran
  • Thymidine