Abstract
In multiple sclerosis, a complex neurodegenerative disorder, a combination of genetic and environmental factors results in inflammation and myelin damage. Recent transcription-profiling studies have found distinct gene-expression patterns in diseased tissue; such large-scale studies at different stages of the disease are contributing to understanding multiple sclerosis and developing effective therapy.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Gene Expression Profiling / methods
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Gene Expression Profiling / standards
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Gene Expression Regulation / genetics*
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Gene Library
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Humans
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Longitudinal Studies
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Multiple Sclerosis / genetics*
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Multiple Sclerosis / pathology
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Oligonucleotide Array Sequence Analysis / methods
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Oligonucleotide Array Sequence Analysis / standards