Development of a donor-acceptor concept for enzymatic cross-coupling reactions of aldehydes: the first asymmetric cross-benzoin condensation

Pascal Dünkelmann; Doris Kolter-Jung; Adam Nitsche; Ayhan S Demir; Petra Siegert; Bettina Lingen; Martin Baumann; Martina Pohl; Michael Müller

doi:10.1021/ja0271476

Development of a donor-acceptor concept for enzymatic cross-coupling reactions of aldehydes: the first asymmetric cross-benzoin condensation

J Am Chem Soc. 2002 Oct 16;124(41):12084-5. doi: 10.1021/ja0271476.

Authors

Pascal Dünkelmann¹, Doris Kolter-Jung, Adam Nitsche, Ayhan S Demir, Petra Siegert, Bettina Lingen, Martin Baumann, Martina Pohl, Michael Müller

Affiliation

¹ Institute of Biotechnology 2, Forschungszentrum Jülich, 52425 Jülich, Germany.

PMID: 12371834
DOI: 10.1021/ja0271476

Abstract

Highly enantioenriched mixed benzoins are obtained selectively through a biocatalytical cross-coupling reaction of aromatic aldehydes using ThDP-dependent enzymes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aldehyde-Lyases / chemistry*
Benzaldehydes / chemistry*
Benzoin / analogs & derivatives*
Benzoin / chemical synthesis
Benzoin / chemistry
Carboxy-Lyases / chemistry*
Catalysis
Kinetics

Substances

Benzaldehydes
Carboxy-Lyases
benzoylformate decarboxylase
Aldehyde-Lyases
benzaldehyde lyase
Benzoin