Abstract
The present review concentrates on camptothecin (CPT) analogues, the most extensively studied topoisomerase I (topo I) inhibitors, and provides concise information on the structural features of human topo I enzyme, mechanisms of interaction of CPT with topo I, structure-activity relationship study of CPT analogues including the influence of lactone stability on antitumor activity, and recent updates of valuable CPT analogues.
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / pharmacology*
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Antineoplastic Agents, Phytogenic / therapeutic use
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Camptothecin / analogs & derivatives*
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Camptothecin / chemistry
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Camptothecin / pharmacology
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Camptothecin / therapeutic use
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Clinical Trials as Topic
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology*
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Enzyme Inhibitors / therapeutic use
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Humans
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Molecular Structure
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Neoplasms / drug therapy
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Neoplasms / enzymology
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Structure-Activity Relationship
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Topoisomerase I Inhibitors*
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Treatment Outcome
Substances
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Antineoplastic Agents, Phytogenic
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Enzyme Inhibitors
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Topoisomerase I Inhibitors
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Camptothecin