Abstract
Alpha(V)beta(3) integrin, a cell surface protein, has been targeted by a variety of natural and synthetic antagonists in the search for potential cancer and osteoporosis drug candidates. This review discusses chemical and structural requirements for activity and selectivity deduced from SAR studies and draws a tentative picture of the pharmacophore.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Benzodiazepines / chemistry
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Benzodiazepines / pharmacology*
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Drug Design*
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Integrin alphaVbeta3 / antagonists & inhibitors*
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Peptides, Cyclic / chemistry
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Peptides, Cyclic / pharmacology*
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Structure-Activity Relationship
Substances
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Integrin alphaVbeta3
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Peptides, Cyclic
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Benzodiazepines