Low blood dendritic cells in chronic myeloid leukaemia patients correlates with loss of CD34+/CD38- primitive haematopoietic progenitors

Br J Haematol. 2002 Oct;119(1):115-8. doi: 10.1046/j.1365-2141.2002.03831.x.

Abstract

Myeloid and plasmacytoid dendritic cells (MDC, PDC) play a key role in the initiation of immune responses. We found a reduction of DC subsets among 20 chronic myeloid leukaemia (CML) patients in chronic phase (MDC, mean, 0.10% +/- 0.10, P = 0.02; PDC, mean, 0.11% +/- 0.08, P = 0.006 versus controls). The maintenance of blood DC correlated with the presence of high percentages of circulating CD34+/CD38- progenitors that were able to give rise in vitro to CD1a+ DC. The reduced DC numbers may contribute to leukaemia escape from immune control and restoration of DC may be a goal for CML immunotherapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • ADP-ribosyl Cyclase / immunology*
  • ADP-ribosyl Cyclase 1
  • Adult
  • Aged
  • Aged, 80 and over
  • Antigens, CD / immunology*
  • Antigens, CD1 / immunology
  • Antigens, CD34 / immunology*
  • Dendritic Cells / immunology*
  • Female
  • Hematopoietic Stem Cells / immunology*
  • Humans
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / blood*
  • Male
  • Membrane Glycoproteins
  • Middle Aged

Substances

  • Antigens, CD
  • Antigens, CD1
  • Antigens, CD34
  • CD1a antigen
  • Membrane Glycoproteins
  • ADP-ribosyl Cyclase
  • CD38 protein, human
  • ADP-ribosyl Cyclase 1