Chabamide, a novel piperine dimer from stems of Piper chaba

Planta Med. 2002 Sep;68(9):853-5. doi: 10.1055/s-2002-34410.

Abstract

A novel piperine dimer, named chabamide, was isolated from stems of Piper chaba Hunter and its structure was elucidated on the basis of spectroscopic evidence. Chabamide showed antimalarial activity with an IC(50) value of 2.7 microg/ml and antituberculosis activity with the minimum inhibitory concentration (MIC) of 12.5 microg/ml.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids*
  • Animals
  • Antimalarials / chemistry
  • Antimalarials / isolation & purification
  • Antimalarials / pharmacology
  • Antitubercular Agents / chemistry
  • Antitubercular Agents / isolation & purification
  • Antitubercular Agents / pharmacology
  • Benzodioxoles
  • Dimerization
  • Inhibitory Concentration 50
  • Magnetic Resonance Spectroscopy
  • Mycobacterium tuberculosis / drug effects
  • Piper*
  • Piperidines / chemistry*
  • Piperidines / isolation & purification
  • Piperidines / pharmacology
  • Plant Extracts / chemistry*
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology
  • Plant Stems / chemistry*
  • Plasmodium falciparum / drug effects
  • Polyunsaturated Alkamides

Substances

  • Alkaloids
  • Antimalarials
  • Antitubercular Agents
  • Benzodioxoles
  • Piperidines
  • Plant Extracts
  • Polyunsaturated Alkamides
  • chabamide
  • piperine