Abstract
Cationic Lewis acid complexes [Sc(pyridyl-bis(oxazolinyl)](Cl(2))SbF(6) 1a and 1b catalyze aldol reactions with ethyl glyoxylate with enantioselectivities ranging from 90 to 99% ee and syn reaction diastereoselections ranging from 90:10 to 95:5. [reaction: see text]
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Acids, Heterocyclic / chemistry*
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Aldehydes / chemistry*
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Catalysis
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Cations / chemistry
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Esters / chemistry*
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Glyoxylates / chemistry*
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Models, Molecular
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Molecular Conformation
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Molecular Structure
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Scandium / chemistry*
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Stereoisomerism
Substances
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Acids, Heterocyclic
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Aldehydes
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Cations
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Esters
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Glyoxylates
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3-hydroxybutanal
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Scandium