Fluoroquinolone-resistant Streptococcus pneumoniae strains occur frequently in elderly patients in Japan

Antimicrob Agents Chemother. 2002 Oct;46(10):3311-5. doi: 10.1128/AAC.46.10.3311-3315.2002.

Abstract

We identified and genetically characterized seven fluoroquinolone-resistant Streptococcus pneumoniae strains among 293 clinical strains isolated from 1999 to 2001 in Japan. The resistant strains were isolated only from adults, and 7 of 31 isolates (22.6%) were from patients more than 20 years old. Resistant strains were not found in 262 isolates from children under age 10.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Anti-Infective Agents / pharmacology*
  • Child
  • Child, Preschool
  • DNA Gyrase / genetics
  • DNA Topoisomerase IV / genetics
  • Drug Resistance, Bacterial*
  • Female
  • Fluoroquinolones
  • Humans
  • Infant
  • Japan / epidemiology
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged
  • Molecular Sequence Data
  • Pneumococcal Infections / epidemiology*
  • Pneumococcal Infections / microbiology
  • Sequence Analysis, DNA
  • Streptococcus pneumoniae / drug effects*

Substances

  • Anti-Infective Agents
  • Fluoroquinolones
  • DNA Topoisomerase IV
  • DNA Gyrase

Associated data

  • GENBANK/AF503576
  • GENBANK/AF503577