Abstract
We identified and genetically characterized seven fluoroquinolone-resistant Streptococcus pneumoniae strains among 293 clinical strains isolated from 1999 to 2001 in Japan. The resistant strains were isolated only from adults, and 7 of 31 isolates (22.6%) were from patients more than 20 years old. Resistant strains were not found in 262 isolates from children under age 10.
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Anti-Infective Agents / pharmacology*
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Child
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Child, Preschool
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DNA Gyrase / genetics
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DNA Topoisomerase IV / genetics
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Drug Resistance, Bacterial*
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Female
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Fluoroquinolones
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Humans
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Infant
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Japan / epidemiology
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Male
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Microbial Sensitivity Tests
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Middle Aged
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Molecular Sequence Data
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Pneumococcal Infections / epidemiology*
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Pneumococcal Infections / microbiology
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Sequence Analysis, DNA
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Streptococcus pneumoniae / drug effects*
Substances
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Anti-Infective Agents
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Fluoroquinolones
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DNA Topoisomerase IV
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DNA Gyrase
Associated data
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GENBANK/AF503576
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GENBANK/AF503577