Diseases in fish are serious problems for the development of aquaculture. The outbreak of fish disease is largely dependent on environmental and endogenous factors resulting in opportunistic infection. Recent studies, particularly on stress response, have revealed that bidirectional communication between the endocrine and immune systems via hormones and cytokines exists at the level of teleost fish. Recently information on such messengers and receptors has accumulated in fish research particularly at the molecular level. Furthermore, it has become apparent in fish that cells of the immune system produce or express hormones and their receptors and vice versa to exchange information between the two systems. This review summarizes and updates the knowledge on endocrine-immune interactions in fish with special emphasis on the roles of such mediators or receptors for their interactions.