Sesquiterpenes with hepatoprotective activity from Cnidium monnieri on tacrine-induced cytotoxicity in Hep G2 cells

Planta Med. 2002 Aug;68(8):748-9. doi: 10.1055/s-2002-33796.

Abstract

Bioassay-guided fractionation of the EtOH extract of Cnidium monnieri (Apiaceae) furnished two hepatoprotective sesquiterpenes, torilin (1) and torilolone (2), together with a new derivative, 1-hydroxytorilin (3). Compounds 1 and 2 showed hepatoprotective effects on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells. The EC50 values of compounds 1 and 2 were 20.6 +/- 1.86 (P < 0.01) and 3.6 +/- 0.1 (P < 0.01) microM, respectively. Silybin as a positive control showed an EC50 value of 69.0 +/- 3.4 microM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cnidium / chemistry*
  • Fruit / chemistry
  • Hepatocytes / drug effects*
  • Hepatocytes / pathology
  • Humans
  • Molecular Structure
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology
  • Plants, Medicinal / chemistry
  • Sesquiterpenes / isolation & purification*
  • Sesquiterpenes / pharmacology*
  • Tacrine / antagonists & inhibitors*
  • Tacrine / toxicity
  • Tumor Cells, Cultured

Substances

  • Plant Extracts
  • Sesquiterpenes
  • Tacrine