The role of the left frontal lobe in action naming: rTMS evidence

Neurology. 2002 Sep 10;59(5):720-3. doi: 10.1212/wnl.59.5.720.

Abstract

Background: Neuropsychological and neuroimaging studies suggest that whereas the left temporal neocortex plays a crucial role in all tasks involving lexical-semantic processing, some regions of the left prefrontal convexity are selectively recruited during verb processing.

Objective: To determine if there are different neural correlates for noun and verb processing in the human brain.

Methods: Repetitive transcranial magnetic stimulation (rTMS), 20 Hz at 90% of the motor threshold, was applied to left or right prefrontal brain during object- and action-naming tasks in nine healthy subjects.

Results: A shortening of naming latency for actions was observed only after stimulation of left prefrontal cortex.

Conclusion: The involvement of the left dorsolateral frontal cortex in action naming was demonstrated using rTMS.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Electric Stimulation
  • Female
  • Functional Laterality / physiology
  • Humans
  • Language*
  • Magnetics*
  • Male
  • Photic Stimulation
  • Prefrontal Cortex / physiology*
  • Reaction Time / physiology