[18F]-Dopa positron emission tomography imaging in early-stage, non-parkin juvenile parkinsonism

Mov Disord. 2002 Jul;17(4):789-94. doi: 10.1002/mds.10133.

Abstract

There are few reports of positron emission tomography (PET) in juvenile parkinsonism (JP). We report on the results of (18)F-6-fluoro-L-dopa (FD) PET in a 14-year-old patient with JP of 5 years duration associated with atypical features. This is the youngest subject to be investigated to date. There was a severe asymmetric reduction in striatal FD uptake, with a rostrocaudal gradient in the putamen similar to that seen in adult-onset idiopathic parkinsonism. Extensive DNA analysis in this patient did not show mutations in the parkin gene.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Caudate Nucleus / diagnostic imaging
  • Caudate Nucleus / physiopathology
  • Corpus Striatum / diagnostic imaging*
  • Corpus Striatum / physiopathology
  • DNA Mutational Analysis
  • Dihydroxyphenylalanine / analogs & derivatives*
  • Dominance, Cerebral / physiology
  • Gene Expression / physiology
  • Humans
  • Image Processing, Computer-Assisted
  • Imaging, Three-Dimensional
  • Ligases / genetics*
  • Male
  • Neurologic Examination
  • Parkinsonian Disorders / diagnostic imaging*
  • Parkinsonian Disorders / genetics
  • Putamen / diagnostic imaging
  • Putamen / physiopathology
  • Tomography, Emission-Computed / methods*
  • Ubiquitin-Protein Ligases*

Substances

  • fluorodopa F 18
  • Dihydroxyphenylalanine
  • Ubiquitin-Protein Ligases
  • parkin protein
  • Ligases